Key Safety Update The MHRA has removed the post-operative pain indication from all prolonged-release opioid medicines. This change reflects growing evidence of the risk of persistent post-operative opioid use (PPOU) and opioid-induced ventilatory impairment in this patient group. What Has Changed Prolonged-release opioid formulations are no longer licensed for the relief of post-operative pain. This […]
MHRA Alert – Valproate: Two-Specialist Review Now Required for New Patients Under 55
Key Update on Valproate Initiation Requirements The Commission on Human Medicines (CHM) has clarified prescribing requirements for valproate, a medication used to treat epilepsy and other conditions. Two specialist reviews are now mandatory for all patients under 55 years of age initiating valproate, regardless of sex or gender. Important Clarification for Existing Male Patients Male […]